Title : Dysfunction of pulmonary epithelial tight junction induced by silicon dioxide nanoparticles via the ROS/ERK pathway and protein degradation.

Pub. Date : 2020 Sep

PMID : 32387908






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 In addition, SiNP exposure increased reactive oxygen species (ROS) production and activated extracellular regulated protein kinases (ERKs) and c-Jun N-terminal kinase (JNK). sinp mitogen-activated protein kinase 1 Homo sapiens
2 The inhibition of ROS and ERKs effectively protected the SiNP-induced downregulation of ZO-1 mRNA and protein expression, but had no effect on ZO-2 or occludin expression. sinp mitogen-activated protein kinase 1 Homo sapiens