Title : Novel pyrrolobenzodiazepine benzofused hybrid molecules inhibit NF-κB activity and synergise with bortezomib and ibrutinib in hematological cancers.

Pub. Date : 2021 Apr 1

PMID : 32381576






1 Functional Relationships(s)
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1 Given that NF-kappaB plays a role in both bortezomib and ibrutinib resistance mechanisms, these data provide a strong rationale for the use of DC-1-192 in the treatment of NF-kappaB-driven cancers, particularly in the context of relapsed/refractory disease. ibrutinib nuclear factor kappa B subunit 1 Homo sapiens