Title : The mechanism of loop C-neonicotinoid interactions at insect nicotinic acetylcholine receptor α1 subunit predicts resistance emergence in pests.

Pub. Date : 2020 May 5

PMID : 32371996






2 Functional Relationships(s)
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1 Thus, we have investigated the effects of S221A and S221Q mutations in loop C of the Drosophila melanogaster Dalpha1 subunit on the agonist activity of imidacloprid and thiacloprid for Dalpha1/chicken beta2 nAChRs expressed in Xenopus laevis oocytes. thiacloprid ATPase H+ transporting V0 subunit a2 Gallus gallus
2 The S221A mutation hardly affected either the affinity or efficacy for ACh and imidacloprid, whereas it only slightly reduced the efficacy for thiacloprid on the nAChRs with a higher composition ratio of beta2 to Dalpha1 subunits. thiacloprid ATPase H+ transporting V0 subunit a2 Gallus gallus