Pub. Date : 2020 May 1
PMID : 32370011
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CDDO-Me Inhibits Microglial Activation and Monocyte Infiltration by Abrogating NFkappaB- and p38 MAPK-Mediated Signaling Pathways Following Status Epilepticus. | bardoxolone methyl | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Furthermore, CDDO-Me inhibited nuclear factor-kappaB (NFkappaB)-S276 phosphorylation and microglial transformation, independent of Nrf2 expression. | bardoxolone methyl | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Therefore, these findings suggest, for the first time, that CDDO-Me may attenuate microglia/monocyte-mediated neuroinflammation via modulating NFkappaB- and p38 MAPK-MCP-1 signaling pathways following SE. | bardoxolone methyl | nuclear factor kappa B subunit 1 | Homo sapiens |