Title : Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERα expression in high-grade serous ovarian carcinoma.

Pub. Date : 2020

PMID : 32368395






1 Functional Relationships(s)
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1 Our recent study demonstrated that pharmacological inhibition of CDK2 or enhancer of zeste homolog 2 (EZH2) allows re-expression of ERalpha and converts triple-negative breast cancers (TNBC) to luminal ERalpha-positive, rendering TNBC cells targetable by tamoxifen. Tamoxifen cyclin dependent kinase 2 Homo sapiens