Title : Mitochondrial energy metabolism is negatively regulated by cannabinoid receptor 1 in intact human epidermis.

Pub. Date : 2020 Jul

PMID : 32367548






4 Functional Relationships(s)
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1 Using organ-cultured full-thickness human skin specimens of healthy individuals, we showed that antagonizing the homeostatic CB1 signaling by the administration of the CB1 inverse agonist AM251 increased activity of respiratory chain complex I and II/IV activity in a CB1 -dependent manner, since the CB1 -selective agonist arachidonyl-2"-chloroethylamide could prevent the effect. arachidonyl-2-chloroethylamide cannabinoid receptor 1 Homo sapiens
2 Using organ-cultured full-thickness human skin specimens of healthy individuals, we showed that antagonizing the homeostatic CB1 signaling by the administration of the CB1 inverse agonist AM251 increased activity of respiratory chain complex I and II/IV activity in a CB1 -dependent manner, since the CB1 -selective agonist arachidonyl-2"-chloroethylamide could prevent the effect. arachidonyl-2-chloroethylamide cannabinoid receptor 1 Homo sapiens
3 Using organ-cultured full-thickness human skin specimens of healthy individuals, we showed that antagonizing the homeostatic CB1 signaling by the administration of the CB1 inverse agonist AM251 increased activity of respiratory chain complex I and II/IV activity in a CB1 -dependent manner, since the CB1 -selective agonist arachidonyl-2"-chloroethylamide could prevent the effect. arachidonyl-2-chloroethylamide cannabinoid receptor 1 Homo sapiens
4 Using organ-cultured full-thickness human skin specimens of healthy individuals, we showed that antagonizing the homeostatic CB1 signaling by the administration of the CB1 inverse agonist AM251 increased activity of respiratory chain complex I and II/IV activity in a CB1 -dependent manner, since the CB1 -selective agonist arachidonyl-2"-chloroethylamide could prevent the effect. arachidonyl-2-chloroethylamide cannabinoid receptor 1 Homo sapiens