Title : Low-Molecular-Weight Heparin Reduces Ventilation-Induced Lung Injury through Hypoxia Inducible Factor-1α in a Murine Endotoxemia Model.

Pub. Date : 2020 Apr 28

PMID : 32353952






2 Functional Relationships(s)
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1 Endotoxin-induced augmentation of VILI and epithelial apoptosis were reduced in the HIF-1alpha-deficient mice and in the wild-type mice following enoxaparin administration (p < 0.05). Enoxaparin hypoxia inducible factor 1, alpha subunit Mus musculus
2 Our data suggest that enoxaparin reduces endotoxin-augmented MV-induced ALI, partially by inhibiting the HIF-1alpha pathway. Enoxaparin hypoxia inducible factor 1, alpha subunit Mus musculus