Pub. Date : 2020 May 29
PMID : 32347294
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Small molecule H89 renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors. | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | ribosomal protein S6 kinase B1 | Homo sapiens |
| 2 | Here, we report that H89 (N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide), a well-characterized ATP-mimetic kinase inhibitor, renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors across multiple cell lines. | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | ribosomal protein S6 kinase B1 | Homo sapiens |
| 3 | Here, we report that H89 (N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide), a well-characterized ATP-mimetic kinase inhibitor, renders the phosphorylation of S6K1 and AKT resistant to mTOR inhibitors across multiple cell lines. | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | ribosomal protein S6 kinase B1 | Homo sapiens |
| 4 | Moreover, H89 prevented the dephosphorylation of AKT and S6K1 under nutrient depleted conditions. | N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide | ribosomal protein S6 kinase B1 | Homo sapiens |