Pub. Date : 2020 Sep 21
PMID : 32347098
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | GPR40 agonist GW9508 ameliorates oxidized LDL-induced endothelial dysfunction via the AMPK/CREB/PGC1alpha pathway. | GW9508 | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | Additionally, GW9508 also restored ox-LDL-induced dephosphorylation of cAMP-responsive element-binding protein (CREB), which was also abolished by compound C. Finally, we found that AMPKalpha and CREB participated in mediating the effects of GW9508 on the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitochondrial homeostasis. | GW9508 | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | Additionally, GW9508 also restored ox-LDL-induced dephosphorylation of cAMP-responsive element-binding protein (CREB), which was also abolished by compound C. Finally, we found that AMPKalpha and CREB participated in mediating the effects of GW9508 on the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitochondrial homeostasis. | GW9508 | cAMP responsive element binding protein 1 | Homo sapiens |
| 4 | Additionally, GW9508 also restored ox-LDL-induced dephosphorylation of cAMP-responsive element-binding protein (CREB), which was also abolished by compound C. Finally, we found that AMPKalpha and CREB participated in mediating the effects of GW9508 on the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitochondrial homeostasis. | GW9508 | cAMP responsive element binding protein 1 | Homo sapiens |
| 5 | Additionally, GW9508 also restored ox-LDL-induced dephosphorylation of cAMP-responsive element-binding protein (CREB), which was also abolished by compound C. Finally, we found that AMPKalpha and CREB participated in mediating the effects of GW9508 on the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitochondrial homeostasis. | GW9508 | cAMP responsive element binding protein 1 | Homo sapiens |
| 6 | Additionally, GW9508 also restored ox-LDL-induced dephosphorylation of cAMP-responsive element-binding protein (CREB), which was also abolished by compound C. Finally, we found that AMPKalpha and CREB participated in mediating the effects of GW9508 on the expression of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) and mitochondrial homeostasis. | GW9508 | cAMP responsive element binding protein 1 | Homo sapiens |