Pub. Date : 2020 Jun
PMID : 32346444
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Naringin promoted the apoptosis of CRC cells and inhibited the activation of the PI3K/AKT/mTOR signaling pathway in a dose-dependent manner. | naringin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway. | naringin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | Naringin has an inhibitory effect on the PI3k/AKT/mTOR signaling pathway in various tumor cell types and the effect of naringin is closely related to the occurrence and proliferation of tumor cells. | naringin | mechanistic target of rapamycin kinase | Homo sapiens |
| 4 | The aim of this present study was to investigate whether naringin could inhibit the proliferation of CRC cells by inhibiting the PI3K/AKT/mTOR signaling pathway. | naringin | mechanistic target of rapamycin kinase | Homo sapiens |
| 5 | The expression levels of PI3K/AKT/mTOR-related proteins [PI3K, AKT, mTOR, phosphorylated (p)-PI3K, p-AKT and p-mTOR] after naringin stimulation in CRC cells were detected using western blot assays. | naringin | mechanistic target of rapamycin kinase | Homo sapiens |
| 6 | The results demonstrated that naringin may be a promising therapeutic agent for the treatment of CRC, which may inhibit the proliferation of CRC cells and induce apoptosis by inhibiting the PI3K/AKT/mTOR signaling pathway. | naringin | mechanistic target of rapamycin kinase | Homo sapiens |