Pub. Date : 2020 Jul
PMID : 32342201
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Gefitinib sensitization of cisplatin-resistant wild-type EGFR non-small cell lung cancer cells. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
2 | As EGFR is the most important pro-survival/proliferation signal receptor in NSCLC cells, we aimed at investigating whether cisplatin resistance is related to EGFR activation and further evaluating the combined effects of cisplatin/gefitinib (EGFR-tyrosine kinase inhibitor, EGFR-TKI) on cisplatin-resistant wtEGFR NSCLC cells. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
3 | As EGFR is the most important pro-survival/proliferation signal receptor in NSCLC cells, we aimed at investigating whether cisplatin resistance is related to EGFR activation and further evaluating the combined effects of cisplatin/gefitinib (EGFR-tyrosine kinase inhibitor, EGFR-TKI) on cisplatin-resistant wtEGFR NSCLC cells. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
4 | As EGFR is the most important pro-survival/proliferation signal receptor in NSCLC cells, we aimed at investigating whether cisplatin resistance is related to EGFR activation and further evaluating the combined effects of cisplatin/gefitinib (EGFR-tyrosine kinase inhibitor, EGFR-TKI) on cisplatin-resistant wtEGFR NSCLC cells. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
5 | MATERIALS AND METHODS: EGFR activation was analysed in parental and cisplatin-resistant wtEGFR NSCLC cell lines (H358 and H358R, A549 and A549R). | Cisplatin | epidermal growth factor receptor | Homo sapiens |
6 | RESULTS: EGFR was significantly phosphorylated in cisplatin-resistant wtEGFR NSCLC cells H358R and A549R than their parental cells. | Cisplatin | epidermal growth factor receptor | Homo sapiens |
7 | CONCLUSION: Abnormal activation of EGFR may induce wtEGFR NSCLC cell resistance to cisplatin. | Cisplatin | epidermal growth factor receptor | Homo sapiens |