Title : Gefitinib sensitization of cisplatin-resistant wild-type EGFR non-small cell lung cancer cells.

Pub. Date : 2020 Jul

PMID : 32342201






7 Functional Relationships(s)
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1 Gefitinib sensitization of cisplatin-resistant wild-type EGFR non-small cell lung cancer cells. Cisplatin epidermal growth factor receptor Homo sapiens
2 As EGFR is the most important pro-survival/proliferation signal receptor in NSCLC cells, we aimed at investigating whether cisplatin resistance is related to EGFR activation and further evaluating the combined effects of cisplatin/gefitinib (EGFR-tyrosine kinase inhibitor, EGFR-TKI) on cisplatin-resistant wtEGFR NSCLC cells. Cisplatin epidermal growth factor receptor Homo sapiens
3 As EGFR is the most important pro-survival/proliferation signal receptor in NSCLC cells, we aimed at investigating whether cisplatin resistance is related to EGFR activation and further evaluating the combined effects of cisplatin/gefitinib (EGFR-tyrosine kinase inhibitor, EGFR-TKI) on cisplatin-resistant wtEGFR NSCLC cells. Cisplatin epidermal growth factor receptor Homo sapiens
4 As EGFR is the most important pro-survival/proliferation signal receptor in NSCLC cells, we aimed at investigating whether cisplatin resistance is related to EGFR activation and further evaluating the combined effects of cisplatin/gefitinib (EGFR-tyrosine kinase inhibitor, EGFR-TKI) on cisplatin-resistant wtEGFR NSCLC cells. Cisplatin epidermal growth factor receptor Homo sapiens
5 MATERIALS AND METHODS: EGFR activation was analysed in parental and cisplatin-resistant wtEGFR NSCLC cell lines (H358 and H358R, A549 and A549R). Cisplatin epidermal growth factor receptor Homo sapiens
6 RESULTS: EGFR was significantly phosphorylated in cisplatin-resistant wtEGFR NSCLC cells H358R and A549R than their parental cells. Cisplatin epidermal growth factor receptor Homo sapiens
7 CONCLUSION: Abnormal activation of EGFR may induce wtEGFR NSCLC cell resistance to cisplatin. Cisplatin epidermal growth factor receptor Homo sapiens