Pub. Date : 2020 Jul
PMID : 32337711
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Molecular dissection of ALS-linked TDP-43: involvement of the Gly-rich domain in interaction with G-quadruplex mRNA. | Glycine | TAR DNA binding protein | Homo sapiens |
| 2 | For the molecular dissection of the TDP-43 and G4-RNA interaction, we analyzed it here in vitro and in cultured cells using a set of ten mutant TDP-43 proteins from familial and sporadic ALS patients as well as using the TDP-43 C-terminal Gly-rich domain alone. | Glycine | TAR DNA binding protein | Homo sapiens |
| 3 | Our results altogether indicate the involvement of the Gly-rich region of TDP-43 in the initial recognition and binding of G4-RNA, which then induces tight binding of TDP-43 with target RNAs, supposedly in conjunction with its RNA recognition motifs (RRMs). | Glycine | TAR DNA binding protein | Homo sapiens |
| 4 | Our results altogether indicate the involvement of the Gly-rich region of TDP-43 in the initial recognition and binding of G4-RNA, which then induces tight binding of TDP-43 with target RNAs, supposedly in conjunction with its RNA recognition motifs (RRMs). | Glycine | TAR DNA binding protein | Homo sapiens |