| Protein Name | TAR DNA binding protein |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 23435 |
| Gene Symbol | TARDBP |
| UniProt | Q13148 (TADBP_HUMAN), Q9H256 (Q9H256_HUMAN), A0A024R4E2 (A0A024R4E2_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
249
Total Number of Articles : 344 |
Description |
TAR DNA binding protein |
| Gene Summary |
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008] |
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