Protein Name TAR DNA binding protein
Organism Homo sapiens
Gene ID 23435
Gene Symbol


UniProt Q13148 (TADBP_HUMAN), Q9H256 (Q9H256_HUMAN), A0A024R4E2 (A0A024R4E2_HUMAN)
Relationships Total Number of functionally related compound(s) : 249
Total Number of Articles : 344

TAR DNA binding protein

Gene Summary

HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

  • TAR DNA-binding protein 43
  • TAR DNA-binding protein-43
  • ALS10
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