Title : Eicosapentaenoic acid prevents the progression of intracranial aneurysms in rats.

Pub. Date : 2020 Apr 24

PMID : 32331514






3 Functional Relationships(s)
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1 In in vitro experiments using RAW264.7 cells, pre-treatment of EPA partially suppressed lipopolysaccharide-induced activation of nuclear factor-kappa B and also the transcriptional induction of monocyte chemoattractant protein 1 (MCP-1), a major chemoattractant for macrophages to accumulate in lesions. Eicosapentaenoic Acid chemokine (C-C motif) ligand 2 Mus musculus
2 In in vitro experiments using RAW264.7 cells, pre-treatment of EPA partially suppressed lipopolysaccharide-induced activation of nuclear factor-kappa B and also the transcriptional induction of monocyte chemoattractant protein 1 (MCP-1), a major chemoattractant for macrophages to accumulate in lesions. Eicosapentaenoic Acid chemokine (C-C motif) ligand 2 Mus musculus
3 Consistently, EPA remarkably suppressed MCP-1 expression in lesions, suggesting the in vivo relevance of in vitro studies. Eicosapentaenoic Acid chemokine (C-C motif) ligand 2 Mus musculus