Protein Name C-C motif chemokine ligand 2
Organism Mus musculus
Gene ID 20296
Gene Symbol

Ccl2

UniProt P10148 (CCL2_MOUSE), Q5SVU3 (Q5SVU3_MOUSE)
Relationships Total Number of functionally related compound(s) : 1060
Total Number of Articles : 1534
Description

C-C motif chemokine ligand 2

Gene Summary

This gene is one of several cytokine genes clustered on chromosome 11. Chemokines are a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes and memory T cells but not for neutrophils. The human ortholog has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, such as psoriasis, rheumatoid arthritis, and atherosclerosis. [provided by RefSeq, Sep 2015]

synonyms
  • C-C motif chemokine 2
  • chemokine (C-C motif) ligand 2
  • monocyte chemoattractant protein 1
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Properties