Title : Discovery of novel heat shock protein (Hsp90) inhibitors based on luminespib with potent antitumor activity.

Pub. Date : 2020 Jun 15

PMID : 32305165






1 Functional Relationships(s)
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1 Among the synthesized surrogates of isoxazole and pyrazole, compounds 4a, 5e and 12b exhibited potent Hsp90 inhibition in ATPase activity and Her2 degradation assays and significant antitumor activity in A2780 and HCT116 cell lines. Isoxazoles erb-b2 receptor tyrosine kinase 2 Homo sapiens