Title : Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.

Pub. Date : 2020 Sep 1

PMID : 32301840






1 Functional Relationships(s)
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1 Our data support investigating S1PR1 antagonists as a clinical approach to mitigate opioid-induced adverse effects and repurposing the functional S1PR1 antagonist FTY720, which is FDA-approved for multiple sclerosis, as an opioid adjunct. Fingolimod Hydrochloride sphingosine-1-phosphate receptor 1 Mus musculus