Pub. Date : 2020
PMID : 32296336
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we synthesized a series of six barbituric acid (BA) derivatives, and one of the compounds, BA-5, exhibited the best ability to ameliorate TGF-beta1-induced HSC activation without overt cytotoxic effects. | barbituric acid | transforming growth factor, beta 1 | Mus musculus |
| 2 | In this study, we synthesized a series of six barbituric acid (BA) derivatives, and one of the compounds, BA-5, exhibited the best ability to ameliorate TGF-beta1-induced HSC activation without overt cytotoxic effects. | barbituric acid | transforming growth factor, beta 1 | Mus musculus |
| 3 | In conclusion, our study showed that the barbituric acid derivative BA-5 inhibits HSCs activation and liver fibrosis by blocking both the TGF-beta1 and LPS-induced NF-kappaB signaling pathways and further inhibits macrophages recruitment and activation. | barbituric acid | transforming growth factor, beta 1 | Mus musculus |