Protein Name transforming growth factor, beta 1
Organism Mus musculus
Gene ID 21803
Gene Symbol


UniProt P04202 (TGFB1_MOUSE), Q3UNK5 (Q3UNK5_MOUSE)
Relationships Total Number of functionally related compound(s) : 1658
Total Number of Articles : 3177

transforming growth factor, beta 1

Gene Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate a latency-associated peptide (LAP) and a mature peptide, and is found in either a latent form composed of a mature peptide homodimer, a LAP homodimer, and a latent TGF-beta binding protein, or in an active form consisting solely of the mature peptide homodimer. The mature peptide may also form heterodimers with other TGF-beta family members. This encoded protein regulates cell proliferation, differentiation and growth, and can modulate expression and activation of other growth factors including interferon gamma and tumor necrosis factor alpha. Mice lacking a functional copy of this gene develop severe multifocal inflammatory disease, yolk sac defects and colon cancer. [provided by RefSeq, Aug 2016]

  • transforming growth factor beta-1 proprotein
  • TGF-beta1
  • TGFbeta1
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