Pub. Date : 2020 Apr 14
PMID : 32290846
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Chronic morphine regulates TRPM8 channels via MOR-PKCbeta signaling. | Morphine | protein kinase C, alpha | Mus musculus |
| 2 | Our results show that activation of MOR by morphine 1) promotes hyperexcitability of TRPM8-expressing neurons and 2) induces a PKCbeta-mediated reduction of TRPM8 desensitization. | Morphine | protein kinase C, alpha | Mus musculus |
| 3 | This MOR-PKCbeta dependent modulation of TRPM8 may underlie the onset of cold hyperalgesia caused by repeated administration of morphine. | Morphine | protein kinase C, alpha | Mus musculus |