Protein Name protein kinase C, alpha
Organism Mus musculus
Gene ID 18750
Gene Symbol


UniProt P20444 (KPCA_MOUSE), Q4VA93 (Q4VA93_MOUSE)
Relationships Total Number of functionally related compound(s) : 372
Total Number of Articles : 494

protein kinase C, alpha

Gene Summary

Enables calcium-dependent protein kinase C activity and integrin binding activity. Involved in several processes, including modulation of chemical synaptic transmission; positive regulation of bone resorption; and positive regulation of dense core granule biogenesis. Acts upstream of or within several processes, including induction of positive chemotaxis; negative regulation of signal transduction; and regulation of protein phosphorylation. Located in several cellular components, including calyx of Held; intercalated disc; and photoreceptor outer segment. Part of alphav-beta3 integrin-PKCalpha complex. Is active in presynaptic cytosol. Is expressed in several structures, including alimentary system; brain; early embryo; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha). [provided by Alliance of Genome Resources, Apr 2022]

  • protein kinase C alpha type
  • PKC-A
  • PKC-alpha
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