Title : Simvastatin attenuates the lipopolysaccharideinduced inflammatory response of rat pulmonary microvascular endothelial cells by downregulating toll-like receptor 4 expression.

Pub. Date : 2014

PMID : 32288932






1 Functional Relationships(s)
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1 Simvastatin inhibited LPS-induced TLR4 expression at the mRNA and protein levels in a time-dependent manner (p<0.01), and alleviated inflammation in RPMVECs by inhibiting the release of inflammatory factors such as TNF-alpha and iNOS. Simvastatin nitric oxide synthase 2 Rattus norvegicus