Pub. Date : 2019 Oct 11
PMID : 32259069
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine beta-hydroxylase (DBH). | Norepinephrine | dopamine beta-hydroxylase | Rattus norvegicus |
| 2 | One strategy to mitigate the SNS overdrive is by restricting the biosynthesis of norepinephrine via the inhibition of dopamine beta-hydroxylase (DBH). | Norepinephrine | dopamine beta-hydroxylase | Rattus norvegicus |
| 3 | Zamicastat is a new DBH inhibitor that decreases norepinephrine and increases dopamine levels in peripherally sympathetic-innervated tissues. | Norepinephrine | dopamine beta-hydroxylase | Rattus norvegicus |
| 4 | In conclusion, DBH inhibition decreased norepinephrine levels, reduced end-organ damage, and improved cardiometabolic and inflammatory biomarkers in aged male SHRs. | Norepinephrine | dopamine beta-hydroxylase | Rattus norvegicus |