Title : Hepatoprotective effects of melatonin and celecoxib against ethanol-induced hepatotoxicity in rats.

Pub. Date : 2020 Jun

PMID : 32249710






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1 Finally, hepatic cellular apoptosis was clearly obvious in ethanol intoxicated animals using activated JNK staining.Conclusion: These results provided pieces of evidence that the hepatoprotective effect of melatonin and celecoxib is possibly mediated through the modulation of JNK and TNF-alpha signaling pathways with subsequent suppression of inflammatory and apoptotic processes. Ethanol mitogen-activated protein kinase 8 Rattus norvegicus