Title : Patchouli alcohol protects against chronic unpredictable mild stress-induced depressant-like behavior through inhibiting excessive autophagy via activation of mTOR signaling pathway.

Pub. Date : 2020 Jul

PMID : 32244196






4 Functional Relationships(s)
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1 In addition, PA markedly attenuated CUMS-induced mTOR, p70S6K, and 4E-BP-1 phosphorylation reduction in the hippocampus. patchouli alcohol mechanistic target of rapamycin kinase Rattus norvegicus
2 These results indicated that the antidepressant-like effect of PA was correlated with the activation of the mTOR signaling pathway. patchouli alcohol mechanistic target of rapamycin kinase Rattus norvegicus
3 Moreover, behavioral experimental results showed that the antidepressant-like effect of PA was blocked by rapamycin (autophagy inducer and mTOR inhibitor) and chloroquine (autophagic flux inhibitor). patchouli alcohol mechanistic target of rapamycin kinase Rattus norvegicus
4 These results suggest that PA exerted antidepressant-like effect in CUMS rats through inhibiting autophagy, repairing synapse, and restoring autophagic flux in the hippocampus by activating the mTOR signaling pathway. patchouli alcohol mechanistic target of rapamycin kinase Rattus norvegicus