Pub. Date : 2020 Jul 1
PMID : 32236441
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: To investigate the effect of arginine on adrenocorticotropic hormone (ACTH) and cortisol in subjects with and without vasopressin deficiency. | Arginine | proopiomelanocortin | Homo sapiens |
| 2 | INTERVENTION: Arginine infusion with measurement of ACTH, cortisol and copeptin at baseline and 30/45/60/90/120 minutes. | Arginine | proopiomelanocortin | Homo sapiens |
| 3 | RESULTS: We found different response patterns to arginine: In patients with diabetes insipidus (and low stimulated copeptin levels) median [IQR] ACTH and cortisol increased from 22.9 [16.8, 38.7] to 36.6 [26.2, 52.1] ng/l and from 385 [266, 463] to 467 [349, 533] nmol/l, respectively. | Arginine | proopiomelanocortin | Homo sapiens |
| 4 | CONCLUSION: Diabetes insipidus is associated with increased responsiveness of ACTH/cortisol to arginine. | Arginine | proopiomelanocortin | Homo sapiens |