Title : The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells.

Pub. Date : 2020

PMID : 32231733






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 The dual role of BI 2536, a small-molecule inhibitor that targets PLK1, in induction of apoptosis and attenuation of autophagy in neuroblastoma cells. BI 2536 polo like kinase 1 Homo sapiens
2 BI2536, a small molecule inhibitor against PLK1, significantly reduced cell viability in a panel of NB cell lines, with IC50 less than 100 nM. BI 2536 polo like kinase 1 Homo sapiens
3 PLK1 inhibition by BI 2536 treatment induced cell cycle arrest at G2/M phase and cell apoptosis in NB cells. BI 2536 polo like kinase 1 Homo sapiens