Pub. Date : 2020 Jun 30
PMID : 32222530
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin enhances the sensitivity of colorectal cancer cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Moreover, NAC could recover the downregulation of p-PI3K and p-Akt treated with combination of metformin and cisplatin, which subsequently activated the PI3K/Akt signaling pathway. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Taken together, our results demonstrated that metformin enhanced the sensitivity of CRC cells to cisplatin through ROS-mediated PI3K/Akt signaling pathway. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |