Title : The discriminative stimulus effects of epibatidine in C57BL/6J mice.

Pub. Date : 2020 Sep

PMID : 32209809






3 Functional Relationships(s)
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1 Here, we established that the alpha4beta2* nAChR agonist epibatidine can function as a discriminative stimulus in mice. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 The partial alpha4beta2* nAChR agonists varenicline and 2"-fluoro-3"-(4-nitro-phenyl)deschloroepibatidine produced 61 and 69% epibatidine-appropriate responding, respectively. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
3 These results show that epibatidine may be trained as a discriminative stimulus in mice and has utility in elucidating the in-vivo pharmacology of alpha4beta2* nAChR ligands. epibatidine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus