Title : Effects of sorafenib on fibroblast-like synoviocyte apoptosis in rats with adjuvant arthritis.

Pub. Date : 2020 Jun

PMID : 32199349






2 Functional Relationships(s)
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1 There were significant increases in the expression levels of Fas, Caspase-3 and Mcl-1, and significant decreases in NF-kappaB and C-jun expression in AA FLSs treated with sorafenib. Sorafenib caspase 3 Rattus norvegicus
2 In summary, these results demonstrate that sorafenib promotes AA FLS apoptosis, which may be related to the upregulation of Fas and Caspase-3 and downregulation of NF-kappaB and C-jun. Sorafenib caspase 3 Rattus norvegicus