Pub. Date : 2020 Jun
PMID : 32186774
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | miR-10a increases the cisplatin resistance of lung adenocarcinoma circulating tumor cells via targeting PIK3CA in the PI3K/Akt pathway. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
2 | Expression of phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) phosphorylation were also decreased in A549 and H1299 cells compared with CTCs after cisplatin treatment. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |
3 | In conclusion, miR-10a suppressed the PI3K/Akt pathway to strengthen the resistance of CTCs to cisplatin via targeting PIK3CA, providing a new therapeutic target for lung cancer treatment. | Cisplatin | AKT serine/threonine kinase 1 | Homo sapiens |