Title : miR‑10a increases the cisplatin resistance of lung adenocarcinoma circulating tumor cells via targeting PIK3CA in the PI3K/Akt pathway.

Pub. Date : 2020 Jun

PMID : 32186774






3 Functional Relationships(s)
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1 miR-10a increases the cisplatin resistance of lung adenocarcinoma circulating tumor cells via targeting PIK3CA in the PI3K/Akt pathway. Cisplatin AKT serine/threonine kinase 1 Homo sapiens
2 Expression of phosphoinositide 3-kinase (PI3K) and protein kinase B (Akt) phosphorylation were also decreased in A549 and H1299 cells compared with CTCs after cisplatin treatment. Cisplatin AKT serine/threonine kinase 1 Homo sapiens
3 In conclusion, miR-10a suppressed the PI3K/Akt pathway to strengthen the resistance of CTCs to cisplatin via targeting PIK3CA, providing a new therapeutic target for lung cancer treatment. Cisplatin AKT serine/threonine kinase 1 Homo sapiens