Pub. Date : 2018 Aug
PMID : 32186080
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compared with the high glucose group, the apoptosis rate of hippocampal neurons decreased significantly (P < 0.01), and p-Akt/Akt and Bcl-2/Bax increased significantly (P < 0.05)in icariin group and Akt agonist group. | icariin | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 2 | Compared with the high glucose group, the apoptosis rate of hippocampal neurons decreased significantly (P < 0.01), and p-Akt/Akt and Bcl-2/Bax increased significantly (P < 0.05)in icariin group and Akt agonist group. | icariin | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 3 | Compared with the icariin + Akt inhibitor group, the apoptosis rate of hippocampal neurons decreased significantly (P < 0.01), and p-Akt/Akt and Bcl-2/Bax increased significantly (P < 0.01) in icariin group. | icariin | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 4 | CONCLUSION: Icariin could reduce the apoptosis of neurons cultured in high glucose, which may be achieved by increasing the phosphorylation of Akt protein in Akt signal pathway, then increasing the expression of Bcl-2 and inhibiting the expression of Bax. | icariin | AKT serine/threonine kinase 1 | Rattus norvegicus |
| 5 | CONCLUSION: Icariin could reduce the apoptosis of neurons cultured in high glucose, which may be achieved by increasing the phosphorylation of Akt protein in Akt signal pathway, then increasing the expression of Bcl-2 and inhibiting the expression of Bax. | icariin | AKT serine/threonine kinase 1 | Rattus norvegicus |