Pub. Date : 2021 May
PMID : 32176932
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhanced Inflammatory Reaction and Thrombosis in High-Fat Diet-Fed ApoE-/- Mice are Attenuated by Celastrol. | celastrol | apolipoprotein E | Mus musculus |
| 2 | RESULTS: The results demonstrated that the effect of HFD on inflammatory cytokines in mice with apoE-/- background was reversed by celastrol administration, and celastrol treatment inhibited the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1/interleukin-1beta signaling cascades in peripheral blood mononuclear cells from HFD-fed apoE-/- mice. | celastrol | apolipoprotein E | Mus musculus |
| 3 | Furthermore, celastrol inhibited the pro-thrombotic effects of HFD in apoE-/- mice, and the underlying mechanism was mediated, at least partially, through the suppression of matrix metalloproteinase-2 and -9 expression. | celastrol | apolipoprotein E | Mus musculus |
| 4 | CONCLUSIONS: Celastrol administration significantly attenuated HFD-induced inflammatory reaction, platelet aggregation and thrombosis in apoE-/- mice, and celastrol may be used as a drug for the prevention of HFD-induced inflammatory reaction and thrombus. | celastrol | apolipoprotein E | Mus musculus |