PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32176932-0	2021	Enhanced Inflammatory Reaction and Thrombosis in High-Fat Diet-Fed ApoE-/- Mice are Attenuated by Celastrol.	celastrol	98-107	apolipoprotein E	Mus musculus	67-71	
32176932-8	2021	RESULTS: The results demonstrated that the effect of HFD on inflammatory cytokines in mice with apoE-/- background was reversed by celastrol administration, and celastrol treatment inhibited the NOD-like receptor family, pyrin domain containing 3 (NLRP3)/caspase-1/interleukin-1beta signaling cascades in peripheral blood mononuclear cells from HFD-fed apoE-/- mice.	celastrol	161-170	apolipoprotein E	Mus musculus	353-357	
32176932-10	2021	Furthermore, celastrol inhibited the pro-thrombotic effects of HFD in apoE-/- mice, and the underlying mechanism was mediated, at least partially, through the suppression of matrix metalloproteinase-2 and -9 expression.	celastrol	13-22	apolipoprotein E	Mus musculus	70-74	
32176932-11	2021	CONCLUSIONS: Celastrol administration significantly attenuated HFD-induced inflammatory reaction, platelet aggregation and thrombosis in apoE-/- mice, and celastrol may be used as a drug for the prevention of HFD-induced inflammatory reaction and thrombus.	celastrol	13-22	apolipoprotein E	Mus musculus	137-141