Title : Dexmedetomidine inhibits the invasion, migration, and inflammation of rheumatoid arthritis fibroblast-like synoviocytes by reducing the expression of NLRC5.

Pub. Date : 2020 Mar 9

PMID : 32163856






2 Functional Relationships(s)
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1 In adjuvant-induced arthritis (AA) rat models, DEX (10 mug/kg and 20 mug/kg) reduced the pathological score, the arthritis score, paw swelling volume, and the serum levels of IL-1beta, IL-6, IL-17A, and TNF-alpha. Dexmedetomidine interleukin 1 alpha Rattus norvegicus
2 Moreover, by using Western blot and real-time quantitative PCR (RT-qPCR), it was demonstrated that DEX can inhibit the expression of IL-1beta, IL-6, MMP-3, MMP-9 and P-P65 in the synovial tissue of AA rats. Dexmedetomidine interleukin 1 alpha Rattus norvegicus