Title : Biguanides Induce Acute de novo Lipogenesis in Human Primary Sebocytes.

Pub. Date : 2020

PMID : 32158247






1 Functional Relationships(s)
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1 Results: Using human primary sebocytes, we found that biguanides, isotretinoin and azithromycin induced an acute dose and time-dependent increase in [14C]-acetate labeling of neutral lipids, while AICAR, an AMPK activator, inhibited this DNL response. Biguanides protein kinase AMP-activated catalytic subunit alpha 2 Homo sapiens