Title : Structure of an ancestral mammalian family 1B1 cytochrome P450 with increased thermostability.

Pub. Date : 2020 Apr 24

PMID : 32156703






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Whereas extant human CYP1B1 has one molecule of alpha-naphthoflavone in a closed active site, we observed that subtle amino acid substitutions outside the active site in the ancestor CYP1B enzyme yielded an open active site with four ligand copies. alpha-naphthoflavone cytochrome P450 family 1 subfamily B member 1 Homo sapiens