PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32156703-4	2020	Whereas extant human CYP1B1 has one molecule of alpha-naphthoflavone in a closed active site, we observed that subtle amino acid substitutions outside the active site in the ancestor CYP1B enzyme yielded an open active site with four ligand copies.	alpha-naphthoflavone	48-68	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	21-27