Pub. Date : 2020 Mar 7
PMID : 32145743
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | More importantly, germacrone significantly inhibited the expression of PI3K III, LC3, and Beclin-1 in OGD/R-injured PC12 cells, and up-regulated the expressionof PI3K I, Akt, mTOR, and Bcl-2 proteins in cells, and this inhibited or up-regulated effect was reversed by PI3K I inhibitor (ZSTK474). | germacrone | mechanistic target of rapamycin kinase | Rattus norvegicus |
| 2 | CONCLUSION: The above results indicated that germacrone could inhibit the autophagy effect in OGD/R injury model of PC12 cells, the mechanism of inhibition was regulated by PI3K III/Beclin-1/Bcl-2 and PI3K I/Akt/mTOR pathways, thereby improving the cell viability of PC12 cells and playing a neuroprotective role, which provided a new drug for the treatment of OGD/R. | germacrone | mechanistic target of rapamycin kinase | Rattus norvegicus |