Title : 3PO inhibits inflammatory NFκB and stress-activated kinase signaling in primary human endothelial cells independently of its target PFKFB3.

Pub. Date : 2020

PMID : 32130250






1 Functional Relationships(s)
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1 We found that 3PO caused a rapid and transient reduction in IL-1beta- and TNF-induced phosphorylation of both IKKalpha/beta and JNK, thus inhibiting signaling through the NFkappaB and the stress-activated kinase pathways. 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one nuclear factor kappa B subunit 1 Homo sapiens