Title : Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition.

Pub. Date : 2020

PMID : 32123582






1 Functional Relationships(s)
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1 Based on specific chemical descriptors, 110 compounds proceeded into the secondary screening cascade, which then identified seven compounds with maximum ability to reduce MLKL activation, IC50 >100 muM, EC50 2.5-11.5 muM under long-term necroptosis execution in murine fibroblast L929 cells, and full protection from ATP depletion and membrane leakage in human and murine cells. Adenosine Triphosphate mixed lineage kinase domain-like Mus musculus