Pub. Date : 2020
PMID : 32123582
1 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Based on specific chemical descriptors, 110 compounds proceeded into the secondary screening cascade, which then identified seven compounds with maximum ability to reduce MLKL activation, IC50 >100 muM, EC50 2.5-11.5 muM under long-term necroptosis execution in murine fibroblast L929 cells, and full protection from ATP depletion and membrane leakage in human and murine cells. | Adenosine Triphosphate | mixed lineage kinase domain-like | Mus musculus |