| Protein Name | mixed lineage kinase domain-like |
|---|---|
| Organism | Mus musculus |
| Gene ID | 74568 |
| Gene Symbol | Mlkl |
| UniProt | Q9D2Y4 (MLKL_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
107
Total Number of Articles : 96 |
Description |
mixed lineage kinase domain-like |
| Gene Summary |
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015] |
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