Pub. Date : 2020
PMID : 32116704
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Acetylcholine (Ach)-induced response was tested with N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MS-PPOH, CYP-epoxygenase inhibitor; 10-5M) and Ang-II (10-6M). | Acetylcholine | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 2 | Acetylcholine (Ach)-induced response was tested with N-(methylsulfonyl)-2-(2-propynyloxy)-benzenehexanamide (MS-PPOH, CYP-epoxygenase inhibitor; 10-5M) and Ang-II (10-6M). | Acetylcholine | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 3 | However, ACh-induced relaxation was not blocked by MS-PPOH in Cyp2j5-/- : 58.5 +- 5.0%, P > 0.05, but blocked in C57Bl/6: 52.3 +- 7.5%, P < 0.05, and Ang-II reduces ACh-induced relaxation in both Cyp2j5-/- and C57Bl/6 mice (38.8 +- 3.9% and 45.9 +- 7.8, P <0.05). | Acetylcholine | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |
| 4 | Data suggest that ACh-induced relaxation in Cyp2j5-/- mice depends on nitric oxide (NO) but not CYP-epoxygenases, and the NECA-induced different response in male vs. female Cyp2j5-/- mice when Ang-II treated. | Acetylcholine | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | Mus musculus |