Title : Curcumin mediates attenuation of pro-inflammatory interferon γ and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant.

Pub. Date : 2020 Mar

PMID : 32114280






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1 Curcumin mediates attenuation of pro-inflammatory interferon gamma and interleukin 17 cytokine responses in psoriatic disease, strengthening its role as a dietary immunosuppressant. Curcumin interferon gamma Homo sapiens
2 We hypothesized that curcumin could inhibit interferon (IFN)-gamma and interleukin (IL)-17 production in peripheral blood mononuclear cells from patients with psoriasis and psoriatic arthritis (PsA). Curcumin interferon gamma Homo sapiens
3 To this end, we assessed the in vitro effect of curcumin on IFN-gamma production by cluster differentiation (CD)4(+), CD8(+) T cells, natural killer (NK) and NKT cells and on IL-17 production by CD4(+) T cells from 34 patients with psoriatic disease (22 with psoriasis and 12 with PsA); 15 normal subjects were included as healthy controls. Curcumin interferon gamma Homo sapiens
4 Curcumin significantly decreased, in a dose dependent manner, IFNgamma-production by CD4(+) and CD8(+) T cells, and NK and NKT cells in patients with psoriatic disease and healthy controls. Curcumin interferon gamma Homo sapiens
5 In conclusion, curcumin in vitro inhibits pro-inflammatory IFN-gamma and IL-17 production in psoriatic disease, and this may strengthen its role as a dietary immunosuppressant in patients with this disease. Curcumin interferon gamma Homo sapiens