Title : Design, synthesis and evaluation of 3-hydroxypyridin-4-ones as inhibitors of catechol-O-methyltransferase.

Pub. Date : 2021 May

PMID : 32108308






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 However, due to extensive peripheral metabolism by aromatic L-amino acid decarboxylase and catechol-O-methyltransferase (COMT), only a fraction of the levodopa dose reaches the brain unchanged. Levodopa catechol-O-methyltransferase Homo sapiens
2 However, due to extensive peripheral metabolism by aromatic L-amino acid decarboxylase and catechol-O-methyltransferase (COMT), only a fraction of the levodopa dose reaches the brain unchanged. Levodopa catechol-O-methyltransferase Homo sapiens
3 Thus, by preventing levodopa metabolism and increasing the availability of levodopa for uptake into the brain, the inhibition of COMT would be beneficial in Parkinson"s disease. Levodopa catechol-O-methyltransferase Homo sapiens
4 Thus, by preventing levodopa metabolism and increasing the availability of levodopa for uptake into the brain, the inhibition of COMT would be beneficial in Parkinson"s disease. Levodopa catechol-O-methyltransferase Homo sapiens