Pub. Date : 2020 Feb
PMID : 32105160
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: We measured higher proliferation in ER+ breast cancer cells treated with BPA or its replacement, BPS, accompanied by an ERalpha-dependent decrease in genomic DNA hydroxymethylation. | bisphenol A | estrogen receptor 1 | Homo sapiens |
| 2 | On the other hand, we observed that TET2 was negatively regulated by the activation of ERalpha (dimerized and phosphorylated), which was also induced by BPA/BPS binding. | bisphenol A | estrogen receptor 1 | Homo sapiens |
| 3 | CONCLUSIONS: We identified a new feedback circuit of ERalpha activation-DNMT-TET2-DNA hydroxymethylation in ER+ breast cancer cells and uncovered a pivotal role of TET2-mediated DNA hydroxymethylation in modulating BPA/BPS-stimulated proliferation. | bisphenol A | estrogen receptor 1 | Homo sapiens |