Title : Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.

Pub. Date : 2020 Feb 26

PMID : 32101164






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing. Serine clock circadian regulator Homo sapiens
2 We discovered a dynamic serine-rich loop adjacent to the secondary pocket in the photolyase homology region (PHR) domain that regulates differential binding of cryptochromes to the PAS domain core of CLOCK:BMAL1. Serine clock circadian regulator Homo sapiens
3 Notably, binding of the co-repressor PER2 remodels the serine loop of CRY2, making it more CRY1-like and enhancing its affinity for CLOCK:BMAL1. Serine clock circadian regulator Homo sapiens