Title : Evaluation of the Role of P-glycoprotein (P-gp)-Mediated Efflux in the Intestinal Absorption of Common Substrates with Elacridar, a P-gp Inhibitor, in Rats.

Pub. Date : 2020 Jun

PMID : 32078103






1 Functional Relationships(s)
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1 The absorption of oral verapamil, diltiazem and tacrolimus was not influenced by elacridar pre-treatment, and the increase in the AUC0-t of fexofenadine was approximately 3-fold when co-administered with each substrate; the minimal effect of elacridar was attributable to the limited contribution of P-gp but not to their self-inhibition against the transporter. fexofenadine ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus