Title : AMPK activation does not enhance autophagy in neurons in contrast to MTORC1 inhibition: different impact on β-amyloid clearance.

Pub. Date : 2021 Mar

PMID : 32075509






1 Functional Relationships(s)
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1 In contrast, increased activity of AMPK with metformin, AICAR, 2DG, or by gene overexpression did not enhance autophagy but had different effects on Abeta secretion: whereas metformin and 2DG diminished the secreted Abeta levels, AICAR and PRKAA1/AMPK gene overexpression increased them. Metformin amyloid beta (A4) precursor protein Mus musculus