Pub. Date : 2020 Jun
PMID : 32070777
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-kappaB and activates Nrf2 in pancreatic cancer cells. | phenethyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Thus, the aim of this study was to evaluate and compare the effect of PEITC, I3C, XAN, and RES and their combinations on the expression and activation of NF-kappaB and Nrf2 in human PC cell line PANC-1. | phenethyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | The combination of XAN and PEITC also enhanced the activation and expression of Nrf2 and subsequently the expression of GSTP, NQO1, and SOD genes which are controlled by this transcription factor. | phenethyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Modulation of the activity of NF-kappaB and Nrf2 by the combination of XAN and PEITC was found to lead to reduced proliferation of PANC-1 cells. | phenethyl isothiocyanate | NFE2 like bZIP transcription factor 2 | Homo sapiens |